Effects of the SNAP-25 Mnll variant on hippocampal functional connectivity in children with attention deficit/hyperactivity disorder

Objectives Attention-deficit/hyperactivity disorder (ADHD) is one of the most widespread and highly heritable neurodevelopmental disorders affecting children worldwide. Although synaptosomal-associated protein 25 (SNAP-25) a possible gene hypothesized to be associated with working memory deficits in ADHD, little known about its specific impact on hippocampus. The goal current study was determine how variations ADHD’s SNAP-25 Mnll polymorphism (rs3746544) affect hippocampal functional connectivity (FC). Methods A total 88 boys between ages 7 10 years were recruited for study, including 60 patients ADHD 28 healthy controls (HCs). Data from resting-state magnetic resonance imaging (rs-fMRI) clinical information acquired assessed. Two single nucleotide polymorphisms (SNP) genotyped, according which study’s findings separated into two groups: TT homozygotes (TT = 35) G-allele carriers (TG 25). Results Based rs-fMRI data, FC right hippocampus left frontal gyrus evaluated using group-based comparisons. corresponding sensitivities specificities Following comparisons patient groups, different FCs identified. When compared patients, TG had lower precuneus hippocampus, higher middle gyrus. Conclusion fundamental neurological pathways connecting via newly revealed this study. As result, may further serve as an biomarker ADHD.